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Tom6 displays quality features of a tail-anchored protein. The mitochondrial moment protein 1 Mim1 promotes insertion of Tom6 into the outer mitochondrial membrane. Tom6 is thereupon assembled into the TOM complex, a get ready mediated past the sorting and fitting machinery 2. Mim1 itself is regulated alongside a casein kinase 2—dependent phosphorylation incident that stimulates its capacity to denotation other constituents of the TOM complex Tom20 and Tom70 2.

That interconversion of Mim1 chore allows coupling of mitochondrial significance right stuff to the metabolic enterprise of the apartment. The multiplication in steady-state muchos of membrane-integrated, phosphorylated Tom6 promotes the biogenesis of the TOM complex. Surprisingly, an growth in the amount of TOM complex does not top spot to a uncommon acceleration in see predecessor translocation per se; in lieu of, purely purport of a pitiful subset of substrates, namely mitochondrial genome sustenance 1 Mgm1 and vague onions 1.

Fzo1 Unique, is stimulated. How is that substrate selectivity explained?

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